Features of humoral immunity after COVID-19

At the present time, studying humoral immunity to new coronavirus infection is among most important tasks. The COVID-19 induces a protective pool of specific antibodies determining severity and duration such immune protection after convalescence. antibody testing also necessary for assessing efficiency anti-COVID vaccines in order defeat SARS-CoV-2 pandemic. Despite enormous interest scientific community this problem seen literature, there still lack longitudinal observations immunological status (more than 6 months) patients who have undergone COVID-19. aim study long-term monitoring (9-14 development extinction response using quantitative assessment IgA IgG levels peripheral blood had anamnesis. Monitoring anti-SARS-CoV-2 over time has demonstrated significant individual variability, made it possible divide participants into three groups, according characteristic features documented describes each these groups. first group (30% group) exhibited classical pattern viral infection. second (40% participants) presented with high plasma levels, their excess (about 2 times) throughout observation period. third participants), apparently comprised subjects increased Their remain at least 9-10 months onset data obtained confirm which not quite typical infections dynamics sufficiently long period disease (2nd 3rd groups; 70% all volunteers recovered from COVID-19) suggests an role immunoglobulin against responses are very similar behavior other including contacts coronaviruses earlier generations. Humoral may persist more months, thus supporting assumption that naturally infected able resist re-infection time.